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High-Purity API Manufacturing & Global B2B Contract Sourcing Solutions under GMP Compliance

Arecoline Hydrobromide Sourcing Monograph

A Comprehensive Industrial Whitepaper on Sourcing, Synthesis, and Clinical Grade Production for Global Procurement Managers.

1. Molecular & Chemical Foundations of Arecoline HBr

Arecoline Hydrobromide (CAS 300-39-0) is the hydrobromide salt form of the alkaloid arecoline, naturally derived from the seeds of the betel nut palm, Areca catechu, or synthesized through high-yield organic chemical pathways. Chemically identified as methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate; hydrobromide, this molecule exhibits highly active parasympathomimetic properties, functioning as an agonist at muscarinic acetylcholine receptors (M1, M2, M3, and M4 subtypes).

For industrial applications, especially in pharmaceutical R&D and veterinary drug manufacturing, establishing a secure, standard-conforming supply chain is critical. The substance presents as a white crystalline powder, highly soluble in water and ethanol. Our manufacturing lines implement advanced crystallization controls to ensure uniform crystal habit, optimal bulk density, and zero residual solvents (aligned with ICH Q3C Guidelines).

Key Chemical Specifications Table

Parameter Standard (USP / EP Reference) ShineHerb Guaranteed Quality
CAS Number 300-39-0 Verified 300-39-0
Assay (HPLC) ≥ 98.0% ≥ 99.5% (Typical Batch 99.8%)
Melting Point 171 °C to 174 °C 172 °C - 173.5 °C
Heavy Metals ≤ 10 ppm ≤ 5 ppm
Loss on Drying ≤ 1.0% ≤ 0.5%

2. Global Commercial Landscape & Supply Chain Stability

The supply chain for alkaloids such as Arecoline Hydrobromide has faced intense volatility due to shifting regulatory policies, agricultural variability of feedstock materials, and environmental audits in primary industrial manufacturing parks. Global buyers must transition away from intermediary brokers toward verified primary production factories.

Shaanxi ShineHerb Biotech Co., Ltd. resolves this industrial bottleneck by utilizing an integrated supply model. Through our advanced synthesis facilities in Shaanxi Province, we decouple production from agricultural limits. By starting from synthetic nicotinic acid pathways, our chemical processing yields consistent volumes regardless of seasonal harvests. This guarantees global research centers, veterinary labs, and formulation firms an uninterrupted supply route.

3. Macro-Industry Solutions & Application Scenarios

Arecoline Hydrobromide holds a unique therapeutic footprint. Sourcing teams typically represent three primary industries:

  • Veterinary Pharmacology: Famously utilized as an anthelmintic agent (dewormer) specifically targeted toward tapeworm infections in canines, felines, and livestock.
  • Neuroscience and Cognitive Studies: Because of its muscarinic receptor agonist behavior, Arecoline HBr serves as a critical biomarker benchmark tool for studying learning, memory, and parasympathetic pathway stimulations in vivo.
  • Psychopharmacological Research: Crucial for developing novel chemical entities designed to manage cognitive decline, Alzheimer’s symptoms, and receptor binding assays.

4. Quality Control & Regulatory Compliance Pathways

In accordance with Google's search quality guidelines and global E-E-A-T principles, we maintain documentation systems that guarantee raw material traceability. All batches are accompanied by a comprehensive Certificate of Analysis (COA), Fourier-transform Infrared Spectroscopy (FTIR) spectrum reports, and High-Performance Liquid Chromatography (HPLC) chromatograms.

Furthermore, our operations are ISO9001 and GMP-certified. We understand that importing high-purity alkaloids requires navigating complex local customs protocols. ShineHerb Biotech supplies all necessary safety sheets (SDS), non-dangerous chemical declarations, and customs-clearance documentation to ensure seamless regulatory transitions in European, North American, and Asian target ports.

Shaanxi ShineHerb Biotech

A professional B2B pioneer in the extraction, synthesis, and export of high-grade active raw materials for over 20 years.

Our main products include Lactase, Bromelain, Pancreatin, Papain, Quercetin, NAC, PQQ, and Glucosamine Sulfate 2KCL, exported to over 50 countries.

ShineHerb Biotech Factory

Our Global Certifications

Fully compliant with global pharmaceutical and food ingredient distribution standards:

  • GMP & ISO9001
  • FDA Registered
  • Kosher & Halal Certified
  • HACCP & SGS Verified

20+

Years of B2B Sourcing Experience

50+

Countries Exported to Globally

99.8%

Average Batch Chemical Purity

24/7

Dedicated Regulatory Support

Synthesis Optimization & Global Sourcing Roadmap

Ensuring sustainable manufacturing, high product yield, and seamless cross-border shipping logistics.

Step 1: Raw Material Sourcing & Selection

Critical inspection of precursor agents. We use chromatographically certified intermediates to eliminate trace isomers and metal residues at the source.

Step 2: Controlled Catalytic Esterification

The chemical reaction is monitored under real-time HPLC to guide esterification, preventing side-reactions and ensuring maximum yields of arecoline base.

Step 3: Hydrobromination & Recrystallization

Introduction of pharmaceutical-grade hydrobromic acid followed by precise temperature-drop recrystallization to yield pure, ultra-white crystalline salts.

Step 4: Vacuum Drying & Packaging

Double-layered food-grade PE vacuum lining with protective aluminum outer drums prevents humidity absorption and degradation during trans-oceanic shipping.

Original Company Profile & Core Advantages

Welcome to Shaanxi ShineHerb Biotech Co., Ltd., a professional enterprise engaged in the research, production, and exports of Enzyme preparations, Natural plant extracts, Vitamins, Amino acids, and Pharmaceutical intermediates. We are committed to providing global customers with competitive pricing, stable and reliable product quality, and professional, efficient services.

With over 20 years of experience in the raw materials industry, ShineHerb Biotech continues to strengthen its technical capabilities and improve product quality. Our main products include Lactase, Bromelain, Pancreatin, Papain, Quercetin, N-Acetyl-L-Cysteine (NAC), PQQ, and Glucosamine Sulfate 2KCL, among others. These ingredients are widely used in pharmaceuticals, dietary supplements, beverages, cosmetics, and food additives.

Our Core Quality Philosophy

Quality is the core of a company’s survival and development. ShineHerb Biotech has established a strict quality management system, covering raw material inspection, production process control, solvent and excipient management, and final product testing, ensuring rigorous quality control at every stage. Products consistently meet USP, EP, and CP standards.

Manufacturing Facilities & Equipment

Factory Unit
R&D Lab
Synthesis Line
Storage Warehouse
Quality Center
Packaging Line
Control Room

OEM & ODM One-Stop Supplement Manufacturing Service

From formulation and design to production and packaging, we handle every step so you can focus on building your brand.

  • Full Product Range: Powder, Tablets, Hard Capsules, Softgels, Gummies, and Solid Beverages.
  • Private Label Support: Customized labels, formulas, and packaging based on your market requirements.
  • Quality Assurance: GMP & ISO certified manufacturing conforming to US, EU, and other international regulations.
  • Flexible Production Scale: Capable of handling small trial batches up to massive commercial manufacturing orders.

Logistics & International Shipping

We provide hassle-free global shipping options via multi-channel logistics:

  • Express delivery: FedEx, DHL, UPS, EMS
  • By Air cargo shipping
  • By Ocean freight
  • By International railway transportation
  • Full DDU & DDP door-to-door delivery options available
Logistics Center

Videos Showcase

Watch our facility overview and product processing walkthrough:

Official Certifications & Quality Documents

ISO Certification
GMP Certification
FDA Registration
SGS Report
Kosher Certificate
Halal Certificate
HACCP Compliance

Frequently Asked Questions (FAQ)

Technical, regulatory, and sourcing answers for B2B procurement professionals sourcing Arecoline Hydrobromide.

What is the exact assay purity of Arecoline Hydrobromide supplied by your factory? +
We produce industrial and pharmaceutical-grade Arecoline Hydrobromide (CAS 300-39-0) with a guaranteed assay purity of ≥ 98.0% via HPLC analysis. Our standard production batches regularly achieve purities between 99.2% and 99.8%. Batch-specific HPLC chromatograms are included with every shipping batch.
How does Shaanxi ShineHerb Biotech ensure stability and safe transit during export shipping? +
Arecoline Hydrobromide is a hygroscopic crystalline powder that is susceptible to moisture. We package the material in medical-grade double-layered PE bags, hermetically vacuum-sealed inside a moisture-proof aluminum foil pouch. This pouch is packed into heavy-duty 25 kg fiber drums. This multi-layered barrier protects the chemical structure during sea, air, and train transit.
What documentation do you provide to verify compliance for custom imports? +
For smooth custom clearance, we provide a full regulatory documentation pack containing: a Batch Certificate of Analysis (COA), Safety Data Sheets (SDS) matching GHS standards, and commercial export invoices. As an experienced exporter to the US, EU, and Southeast Asia, we help client agents navigate local import requirements.
Can your factory accommodate custom synthesis scales or alternative formulations? +
Yes, our plant is equipped with versatile glass-lined chemical reactors. We offer custom manufacturing services tailored to specific mesh sizes, salt variations, and dry-blends. Please contact our technical team to discuss scale-up requests or specialized packaging needs.
What are the payment terms and minimum order quantities (MOQs) for global buyers? +
Our standard MOQ for specialty active intermediates like Arecoline Hydrobromide starts at 1 kg for research validation. For commercial batches, MOQs are customized based on production campaigns. Payment terms include standard T/T bank transfers, Western Union, and L/C configurations for large enterprise accounts.

Establish Sourcing Partners

Partner with Shaanxi ShineHerb Biotech Co., Ltd. for scalable APIs, botanical extracts, custom formulations, and global compliance support.

Corporate Headquarters: Hi-Tech Zone, Xi'an City, Shaanxi Province, China.
Support Center: 24/7 client portal for quick responses to all technical and bulk pricing inquiries.

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