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A comprehensive overview of how Sclareolide (CAS 564-20-5) has become the cornerstone of modern fine fragrance and biotechnology.
Sclareolide (chemically structured as a sesquiterpene lactone derived from Clary Sage, Salvia sclarea) represents one of the most critical structural components in the global chemical synthesis and perfumery sectors. Over the past decade, the global market for Sclareolide has experienced massive structural growth, driven primarily by the transition from animal-derived raw materials to bio-identical, sustainable plant extracts. Traditionally, the fine fragrance industry relied heavily on ambergris—a naturally occurring substance produced by sperm whales. Due to environmental regulations, marine conservation laws, and severe supply limits, the search for a sustainable molecular alternative became an absolute commercial priority.
This led to the commercial development of Ambroxan (Ambroxide), the compound responsible for the highly sought-after warm, woody, and long-lasting animalic dry-down notes of ambergris. Sclareolide serves as the direct, indispensable precursor for the industrial synthesis of Ambroxide. By employing specialized catalytic oxidation or microbial conversion pathways, raw sclareolide is converted into high-grade Ambroxide. This structural linkage has transformed Sclareolide from a niche agricultural extract into a major global commodity sought by perfume houses, pharmaceutical manufacturers, and premium cosmetic brands across Europe, North America, and the Asia-Pacific region.
Currently, the market demand for wholesale Sclareolide is growing at a compound annual growth rate (CAGR) of over 6.5%. Major luxury fragrance corporations are making public commitments to eliminate synthetic petrochemical-derived base notes and replace them with natural, bio-fermented materials. Beyond perfumery, contemporary research has highlighted Sclareolide’s thermogenic properties, leading to its growing inclusion in weight-management supplements and cosmetic lipolytic formulations. Consequently, ensuring a stable, highly purified, and price-competitive supply of Sclareolide has become a strategic imperative for global chemical brokers and cosmetic ingredient procurers.
The engineering processes behind turning raw botanical biomass into high-purity (98% HPLC) crystalline Sclareolide.
The production begins in premium agricultural regions, where Clary Sage plants are cultivated. The first step involves steam distillation or solvent extraction of the aerial parts of Salvia sclarea to obtain crude Sclareol. This diterpene alcohol is the primary chemical feedstock from which Sclareolide is synthesized.
Traditional chemical pathways utilize oxidizing agents (such as potassium permanganate or chromic acid systems) to split the side-chain of sclareol, transforming it into Sclareolide. Chinese factories have optimized this system using green catalysts, minimizing heavy metals and residual organic solvents.
To meet strict clean-label requirements, advanced manufacturers employ microbial bio-fermentation. Using engineered yeast strains (e.g., *Saccharomyces cerevisiae* or *Yarrowia lipolytica*), glucose or basic lipids are biochemically metabolized directly into high-yield, premium-purity Sclareolide.
Welcome to learn about our company
Shaanxi ShineHerb Biotech Co., Ltd. is a professional enterprise engaged in the research, production, and exports of Enzyme preparations, Natural plant extracts, Vitamins, Amino acids, and Pharmaceutical intermediates. We are committed to providing global customers with competitive pricing, stable and reliable product quality, and professional, efficient services.
With over 20 years of experience in the raw materials industry, ShineHerb Biotech continues to strengthen its technical capabilities and improve product quality. Our main products include Lactase, Bromelain, Pancreatin, Papain, Quercetin, N-Acetyl-L-Cysteine (NAC), PQQ, and Glucosamine Sulfate 2KCL, among others. These ingredients are widely used in pharmaceuticals, dietary supplements, beverages, cosmetics, and food additives.
At present, our products are exported to more than 50 countries and regions, including Europe, North America, and Southeast Asia, and have gained wide recognition and trust from customers worldwide.
Established In
Years Industry Experience
Countries Exported To
Standardized Purity HPLC
How Shaanxi's industrial cluster drives cost efficiency, purity consistency, and supply chain resilience for international markets.
The global chemical and flavor sectors recognize China—particularly Shaanxi province—as the primary industrial hub for the production and export of high-grade Sclareolide. This regional dominance is built on several key factors:
1. Geographic Proximity to Raw Materials: Shaanxi and neighboring provinces boast extensive cultivation fields for Salvia sclarea (Clary Sage). Our direct access to local agricultural harvests eliminates high domestic transit costs for raw biomass, ensuring that our production lines receive freshly harvested materials for initial extraction. This geographic advantage translates into direct cost savings for our global wholesale buyers.
2. Advanced Technological Infrastructure: Over the past two decades, Chinese factories have shifted from labor-intensive processing to fully automated, closed-loop extraction and purification systems. Modern facilities utilize state-of-the-art supercritical carbon dioxide (CO2) extraction methods alongside automated column chromatography. These innovations allow factories to control critical crystal growth factors, consistently yielding Sclareolide with a purity profile exceeding 98% HPLC, while ensuring that the melting point (between 120°C and 124°C) and optical rotation remain within strict specifications.
3. Unmatched Manufacturing Scale: China's industrial scale allows factories to handle massive batch sizes. Whether you need small test batches for R&D or container-load quantities for industrial fragrance production, our production lines can scale up efficiently. We stabilize market pricing through massive inventory reserves and structured, year-round production scheduling, insulating global fragrance brands from seasonal crop failures.
Adhering to strict international standards to ensure product safety, stability, and traceability.
Quality is the core of our survival. ShineHerb Biotech has established a strict quality management system, covering raw material inspection, production process control, solvent management, and final testing, ensuring products meet USP, EP, and CP standards.
We provide comprehensive technical documentation, including HPLC assay sheets, MSDS, batch analysis sheets, heavy metal trace assays, and biological impurity profiles, facilitating seamless registration and formulation.
Our production facilities operate strictly in line with GMP requirements. Each stage is fully documented to guarantee traceability, from harvesting the sage fields to final shipping, ensuring a clean and reliable supply chain.
A technical guide on how Sclareolide is applied across cosmetic science, perfumery synthesis, and agricultural development.
In perfume formulation, Sclareolide is highly valued as a base note fixative. While it doesn't possess the full sensory profile of mature Ambroxide, it brings a clean, dry, woody, and slightly sweet balsamic aroma to perfume bases. Its main function is to slow the evaporation of more volatile top and heart notes, helping the fragrance retain its character over a longer period. Its excellent solubility in ethanol and low skin sensitization profile make it a preferred structural backbone for luxury fragrances.
In cosmetics, Sclareolide is widely used in anti-cellulite and skin-firming products. Clinical research shows that Sclareolide acts as an intracellular adenylate cyclase activator. This process boosts cyclic adenosine monophosphate (cAMP) levels, which helps stimulate lipolysis in adipocytes (fat cells). As a result, it is a key active ingredient in body-sculpting creams, targeting stubborn fat areas. Additionally, its soothing, anti-inflammatory properties make it a valuable addition to formulas designed to calm irritated skin and reduce UV-induced redness.
In agriculture, Sclareolide plays an interesting role in crop protection. It has been shown to induce natural plant defense mechanisms against various fungal and bacterial pathogens. By acting as a mild phytoalexin-inducing agent, spraying Sclareolide in low concentrations helps reduce reliance on harsh chemical fungicides. This application aligns well with the growing global demand for eco-friendly, organic crop protection solutions.
Highly requested bulk ingredients exported to over 50 countries and regions worldwide.
Beyond bulk raw materials, we provide comprehensive OEM & ODM services tailored to your market requirements.
At ShineHerb Biotech, we understand that B2B clients often need more than just standard raw materials. To support our clients' brand development, we offer a comprehensive, one-stop OEM & ODM service. We process raw powders into consumer-ready delivery formats under strict GMP quality standards.
Key Advantages of Our Service:
Our products and facilities are fully certified by the world's leading inspection, quality, and regulatory bodies.
Global Standard Recognition & International Compliance
U.S. Food & Drug Administration Registered & Inspected
Good Manufacturing Practice & Strict Production Hygiene
Guaranteed Hazard Analysis Critical Control Point Management
Approved for Kosher Dietary Applications Globally
Halal Certified for Islamic Dietary Requirements
Verified Batch Quality by Independent Third-Party Testing
Internal HPLC, GC, and Heavy Metal Testing Labs
Take a virtual tour of our production facility and explore our chemical raw material testing processes.
Reliable cargo shipping across multiple transport networks for bulk raw materials.
To ensure raw chemical compounds arrive safely and maintain molecular stability, ShineHerb Biotech offers a robust, temperature-regulated, and multi-channel global distribution network. We provide multiple delivery options to suit your schedule and budget:
Technical, commercial, and operational queries answered by our senior chemical engineers and export managers.
A: Our standard industrial export grade Sclareolide features a purity of ≥98% as determined by High-Performance Liquid Chromatography (HPLC) analysis. For specific cosmetic applications, we can also customize purity levels down to 95%, depending on the target formulation and cost requirements of the buyer.
A: Sclareolide is typically packaged in double-layered, food-grade polyethylene inner bags to shield the crystals from moisture, which are then placed inside 25 kg fiber drums. For smaller trial orders, we use vacuum-sealed aluminum foil bags (1 kg to 5 kg) to maintain chemical stability during transit.
A: Sclareolide is practically insoluble in water. However, it shows excellent solubility in organic solvents like ethanol, diethyl ether, benzene, and toluene, and is moderately soluble in cosmetic oils. This profile makes it easy to integrate into alcohol-based fragrances and oil-in-water cosmetic formulations.
A: Yes. For clients requiring clean-label ingredients, we offer Sclareolide produced via green fermentation or clean extraction methods. These processes use bio-based ethanol instead of chlorinated hydrocarbon solvents, keeping residual solvent levels well below strict USP and EP limits.
A: We maintain a rolling stock of 2 to 5 metric tons of standard 98% Sclareolide at our Shaanxi warehouse. This allows us to dispatch orders up to 1 ton within 5 to 7 business days. For larger custom runs, the lead time is generally between 15 and 21 days, depending on harvest cycles and capacity.
A: Absolutely. Every shipment goes out with a batch-specific Certificate of Analysis (COA) detailing purity, melting point, moisture, optical rotation, and heavy metal counts. Material Safety Data Sheets (MSDS) and independent third-party lab verifications (like SGS or Eurofins reports) are also available upon request.
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