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An authoritative analysis of CAS 300-62-9 chemical synthesis, pharmaceutical efficacy, and structural characterization.
Arecoline Hydrobromide is the hydrobromide salt form of the naturally occurring alkaloid arecoline, predominantly found in the seeds of the betel nut palm, Areca catechu. As a partial agonist of the muscarinic acetylcholine receptors (specifically M1, M2, and M3 subtypes) and nicotinic acetylcholine receptors, Arecoline HBr serves as a critical biochemical probe in neurochemical and cognitive science research.
From an industrial perspective, synthesizing high-purity Arecoline Hydrobromide requires extreme precision in crystallization control and residue solvent management. Standard commercial applications cross into veterinary antiparasitic formulations, agricultural pest control solutions, and primary pharmacological studies mapping central nervous system (CNS) stimulants.
Our facility leverages advanced green chemistry methodologies to synthesize Arecoline HBr with an assay purity surpassing 99.0%. By employing standardized crystallization under GMP guidelines, we minimize the presence of related alkaloids such as arecaidine and guvacine, guaranteeing reliable batches for sensitive analytical applications.
| Specification Parameter | Standard Criteria (Pharmaceutical Grade) | Analytical Verification Method |
|---|---|---|
| Chemical Name | Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide | IUPAC Nomenclature & Structure Match |
| CAS Number | 300-62-9 | Registered Database Verification |
| Molecular Formula | C8H13NO2·HBr | Mass Spectrometry (MS) Verification |
| Assay Purity (HPLC) | ≥ 99.0% (Dry basis) | High-Performance Liquid Chromatography |
| Melting Point Range | 169.0 °C – 173.0 °C | Capillary Melting Point Apparatus |
| Loss on Drying | ≤ 0.5% | Thermogravimetric Analysis (TGA) |
| Heavy Metals (as Pb) | ≤ 10 ppm | ICP-MS Inductively Coupled Plasma |
| Residue Solvents | Conforms to USP <467> (Class II & III) | Headspace Gas Chromatography (HS-GC) |
How multinational organizations manage quality control, regulatory standards, and logistics for complex alkaloids.
Global demand for arecoline derivatives is shifting from traditional natural extraction to high-purity synthetic variants. Advanced laboratories and pharmaceutical compounding facilities require batches that exhibit no organic volatile impurities (OVIs), ensuring stable behavior during downstream chemical assays. Geographically, purchasing offices in North America, Western Europe, and East Asia are expanding procurement programs to secure resilient supply contracts amidst stricter international customs policies.
Arecoline Hydrobromide is classified as a hazardous chemical substance under GHS guidelines (UN 2811, Class 6.1, Packing Group III). Procurement teams must partner with manufacturers capable of producing accurate Safety Data Sheets (SDS), conforming to international customs standards. We provide complete dangerous goods packaging, utilizing reinforced UN-rated drums fitted with dual-layer anti-static low-density polyethylene bags to ensure transit stability and custom clearance without delays.
E-E-A-T parameters require complete scientific backing. Our facility issues a comprehensive Batch Certificate of Analysis (COA), complete with High-Performance Liquid Chromatography (HPLC) chromatograms, Fourier-Transform Infrared Spectroscopy (FTIR) profiles, and Gas Chromatography-Mass Spectrometry (GC-MS) data for residue solvent detection. This level of technical validation guarantees that downstream compounding matches product design parameters perfectly.
Solving purity bottlenecking, formulation instability, and regulatory challenges for global B2B clients.
Alkaloid synthesis is prone to structural isomers and residual raw materials. By utilizing multi-stage solvent extraction followed by recrystallization in highly monitored, temperature-controlled reactors, we achieve a uniform particle size distribution. This consistency minimizes dust generation during handling and optimizes the dissolution rate of the Arecoline Hydrobromide powder when integrated into custom solvent systems or animal feed pre-mixes.
Additionally, we mitigate potential cross-contamination through dedicated production campaigns. Equipment validation involves highly sensitive swab tests analyzed via LC-MS to verify zero carryover between production lots. These rigorous measures guarantee that every kilogram matches the uncompromising purity profile demanded by analytical laboratories.
A premier enterprise dedicated to research, production, and exports of raw materials with over two decades of technical expertise.
Shaanxi ShineHerb Biotech Co., Ltd., situated in the prestigious Hi-Tech Zone of Xi'an, Shaanxi Province, stands as a professional, research-oriented enterprise. For over 20 years, we have engaged in the research, production, and international export of Enzyme preparations, Natural plant extracts, Vitamins, Amino acids, and Pharmaceutical intermediates.
We are deeply committed to providing global clients with competitive pricing, stable and reliable product quality, and professional, efficient services. By focusing heavily on technical capabilities, our raw material supply chain complies with USP, EP, and CP standards, allowing us to export to over 50 countries and regions including Europe, North America, and Southeast Asia.
Charting the path toward automated synthesis, green biocatalysis, and continuous flow engineering.
Transitioning arecoline hydrogenation and esterification steps to continuous-flow microreactors. This engineering advancement limits thermal fluctuations, lowers solvent consumption by 40%, and increases product yield consistency while maintaining ultra-low impurity profiles.
Developing molecularly imprinted polymers (MIPs) to isolate chiral configurations and structural analogs of arecoline. This will support pioneering research institutions investigating selective agonists for specific muscarinic acetylcholine receptor (mAChR) variants.
Replacing chlorinated reaction media with bio-based green solvents. Our engineering team plans to implement closed-loop distillation systems that reclaim 95% of volatile organic processing chemicals, matching global ESG standards.
Premium enzyme preparations and high-purity nutritional raw materials certified for international standard applications.
Uncompromising reliability in testing and documentation, certified by international assessment bodies.
Quality is the cornerstone of ShineHerb Biotech's operations. Our comprehensive quality management system monitors every stage: raw material validation, solvent safety, mid-stage crystallization, final chemical analysis, and hermetic packaging. By maintaining strict control over volatile impurities and trace heavy metals, we ensure that our bulk products meet USP, EP, and CP standards consistently.
ShineHerb Biotech offers full-format customization solutions. Beyond bulk technical powders, our factory specializes in complex formulation formats, including fine powders, solid beverages, tablets, hard-shell capsules, softgels, and functional gummies. From adjusting particle mesh sizes to customized ingredient blending, we provide turnkey solutions under rigorous GMP conditions.
We facilitate secure door-to-door delivery globally via multiple logistics models: air freight, sea container shipping, rail networks, and specialized express networks (FedEx, DHL, UPS, EMS). We provide comprehensive customs clearing documents and DDU/DDP cargo arrangements, ensuring seamless transport of hazardous classifications and chemical intermediates directly to your facility.
Good Manufacturing Practice standards ensuring rigorous batch safety.
International Organization for Standardization quality management certified.
U.S. Food & Drug Administration compliance and registration verified.
Independent laboratory validation verifying batch chemical composition.
Systematic food and chemical ingredient hazard prevention analysis.
Strict supervision standards confirming product dietary purity.
Process compliance allowing entry to Middle Eastern and Asian markets.
Full manufacturing lifecycle verification and internal audits.
Take a virtual tour of Shaanxi ShineHerb Biotech's research facility, laboratory setups, and production lines.
Clear, authoritative technical and logistical answers regarding the procurement of Arecoline Hydrobromide Powder.
Ensure supply resilience by reviewing our broader catalog of high-purity chemical intermediates and premium botanical extracts.
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