Nattokinase, also known as subtilisin (hereinafter referred to as NK), is a serine protease produced by Bacillus subtilis natto during the fermentation of natto. It can dissolve thrombi, reduce blood viscosity, improve blood circulation, soften blood vessels and enhance vascular elasticity.
Product Features
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Produced via liquid fermentation and nanobiotechnology, enabling precise extraction of active ingredients. The product's kinase activity exceeds 50,000 Fu/g.
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Compared with other thrombolytic drugs, Nattokinase (NK) offers advantages including low cost, high safety, small molecular weight, excellent oral efficacy, strong thrombolytic activity and long duration of action.
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Optimal reaction temperature: 30–45°C, with the best performance at 37°C; denatures and inactivates above 80°C. Optimal reaction pH: 6–9, with the best performance at pH 7.4; inactivates below pH 5.
Bacillus subtilis natto fermentation
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Extraction
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Horizontal spiral separation
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Centrate
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High-speed tubular centrifugation
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Centrate
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Microfiltration
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Ultrafiltration
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Re-extraction
← Residue (Discard)
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Vacuum freeze-drying
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Shatter
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Blend
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Detection
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Packaging
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Finished Product
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acceptance (Excipients)
acceptance (Inner packaging bag)
Enzyme Activity Definition: Nattokinase reacts with fibrin to hydrolyze the peptide bonds of fibrin. The hydrolysis reaction changes the absorbance of the solution at 275 nm of ultraviolet light. One activity unit (1 FU) refers to the energy consumed for every 0.01 increase in the absorbance value at 275 nm.
Frequently Asked Questions (FAQ)
What is Nattokinase and how is it produced?
Nattokinase (NK) is a serine protease extracted from natto, a traditional Japanese fermented soybean food. It is produced by Bacillus subtilis natto during fermentation. Our Nattokinase is manufactured using liquid fermentation combined with nanobiotechnology, which enables precise extraction of active ingredients and ensures a kinase activity exceeding 50,000 Fu/g.
What are the main health benefits of Nattokinase?
Nattokinase offers multiple health benefits including dissolving blood clots, reducing blood viscosity, improving blood circulation, softening blood vessels, and enhancing vascular elasticity. It also supports cardiovascular and cerebrovascular health, aids hormone balance, assists with detoxification, improves skin appearance, helps with weight management, and provides antioxidant and anti-fatigue effects.
What are the optimal storage conditions for Nattokinase?
Nattokinase should be stored in a cool, dry, and dark place at a temperature below 0°C. Prolonged or improper storage may reduce enzyme activity. If the product has been exposed to high temperature or humidity, it is recommended to appropriately increase the dosage to compensate for any potential activity loss.
What temperature and pH conditions does Nattokinase work best under?
Nattokinase performs optimally at a reaction temperature of 30–45°C, with peak performance at 37°C (human body temperature). It will denature and become inactivated above 80°C. The optimal pH range is 6–9, with best performance at pH 7.4. The enzyme will be inactivated at pH values below 5.
What packaging options are available for bulk orders?
For small quantities (1kg), the product is packed in a bag/kg with an outer box using double plastic bags plus an aluminum foil bag inside. For larger quantities (10kgs, 25kg or more), the product is packed in drums or cartons with 2 layers of plastic bags inside to ensure product safety and quality during transport.
What shipping methods are available and how long does delivery take?
We offer flexible shipping options to suit different order sizes. Orders of 1kg–25kgs can be shipped via EMS, DHL, UPS, or FedEx with door-to-door delivery in 3–7 days. For 25kgs–100kgs, DHL, FedEx, or Air freight is available with 3–7 day delivery. For orders over 100kgs, air freight (3–7 days) or sea freight (10–35 days) options are available.