Nattokinase, also known as subtilisin (hereinafter referred to as NK), is a serine protease produced by Bacillus subtilis natto during the fermentation of natto. It can dissolve thrombi, reduce blood viscosity, improve blood circulation, soften blood vessels and enhance vascular elasticity.
🔬
Advanced Fermentation Technology: Produced via liquid fermentation and nanobiotechnology, enabling precise extraction of active ingredients. The product's kinase activity exceeds 50,000 Fu/g.
✅
Superior Advantages: Compared with other thrombolytic drugs, Nattokinase (NK) offers advantages including low cost, high safety, small molecular weight, excellent oral efficacy, strong thrombolytic activity and long duration of action.
🌡️
Optimal Reaction Conditions: Temperature: 30–45°C (best at 37°C); denatures above 80°C. pH: 6–9 (best at pH 7.4); inactivates below pH 5.
Bacillus subtilis natto fermentation → Extraction → Horizontal spiral separation → Centrate → High-speed tubular centrifugation → Centrate → Microfiltration → Ultrafiltration ↖ Re-extraction Residue ↓ Discarding → Vacuum freeze-drying → Shatter → Blend → Detection → Packaging → Finished Product ↑ ↑ Acceptance Acceptance ↑ ↑ Excipients Inner packaging bag
💡 Enzyme Activity Definition: Nattokinase reacts with fibrin to hydrolyze the peptide bonds of fibrin. The hydrolysis reaction changes the absorbance of the solution at 275 nm of ultraviolet light. One activity unit (1 FU) refers to the energy consumed for every 0.01 increase in the absorbance value at 275 nm.
Q
What is Nattokinase and where does it come from?
Nattokinase (NK) is a serine protease naturally produced by Bacillus subtilis natto during the fermentation of soybeans (natto). It is extracted and purified using liquid fermentation combined with nanobiotechnology to achieve high enzymatic activity exceeding 50,000 Fu/g.
Q
What are the main health benefits of Nattokinase?
Nattokinase helps dissolve blood clots, reduces blood viscosity, improves blood circulation, and softens blood vessels. It also supports cardiovascular and cerebrovascular health, promotes hormone balance, assists in detoxification and weight management, and offers antioxidant and anti-fatigue benefits.
Q
What are the optimal temperature and pH conditions for Nattokinase activity?
The optimal reaction temperature range is 30–45°C, with peak performance at 37°C. The enzyme denatures and inactivates above 80°C. The optimal pH range is 6–9, with best performance at pH 7.4. Enzyme activity is lost below pH 5.
Q
How should Nattokinase be stored to maintain its activity?
Nattokinase should be stored in a cool, dry, and dark environment at temperatures below 0°C. Prolonged or improper storage — especially exposure to high temperatures or humidity — may reduce enzyme activity. In such cases, a slight increase in dosage is recommended.
Q
What packaging options and minimum order quantities are available?
Nattokinase is available in 1 kg bags (double plastic bag + aluminum foil bag inside a box) as well as 10 kg, 25 kg, or larger quantities packaged in drums or cartons with two layers of plastic bags inside. Custom packaging arrangements can be discussed based on order volume.
Q
What shipping methods are available and what are the delivery times?
For orders of 1–25 kg, express courier services (EMS, DHL, UPS, FedEx) are available with a delivery time of 3–7 days door-to-door. Orders of 25–100 kg ship via DHL, FedEx, or air freight in 3–7 days. Orders over 100 kg can be shipped by air (3–7 days, door to airport) or by sea (10–35 days, door to port).