Nattokinase, also known as subtilisin (hereinafter referred to as NK), is a serine protease produced by Bacillus subtilis natto during the fermentation of natto. It can dissolve thrombi, reduce blood viscosity, improve blood circulation, soften blood vessels and enhance vascular elasticity.
Product Features
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Produced via liquid fermentation and nanobiotechnology, enabling precise extraction of active ingredients. The product's kinase activity exceeds 50,000 Fu/g.
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Compared with other thrombolytic drugs, Nattokinase (NK) offers advantages including low cost, high safety, small molecular weight, excellent oral efficacy, strong thrombolytic activity and long duration of action.
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Optimal reaction temperature: 30–45°C, with the best performance at 37°C; denatures and inactivates above 80°C. Optimal reaction pH: 6–9, with the best performance at pH 7.4; inactivates below pH 5.
Bacillus subtilis natto fermentation → Extraction → Horizontal spiral separation → Centrate → High-speed tubular centrifugation → Centrate → Microfiltration → Ultrafiltration ↑ Re-extraction ← Residue → Discarding → Vacuum freeze-drying → Shatter → Blend → Detection → Packaging → Finished Product ↑ ↑ Acceptance Acceptance ↑ ↑ Excipients Inner packaging bag
💡 Enzyme Activity Definition: Nattokinase reacts with fibrin to hydrolyze the peptide bonds of fibrin. The hydrolysis reaction changes the absorbance of the solution at 275 nm of ultraviolet light. One activity unit (1FU) refers to the energy consumed for every 0.01 increase in the absorbance value at 275 nm.
❓ Frequently Asked Questions (FAQ)
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What is Nattokinase and where does it come from?
Nattokinase (NK) is a serine protease extracted from natto, a traditional Japanese fermented soybean food. It is produced by Bacillus subtilis natto during the fermentation process and is widely recognized for its potent thrombolytic properties.
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What is the enzyme activity level of your Nattokinase product?
Our Nattokinase is produced via liquid fermentation and nanobiotechnology. The kinase activity exceeds 50,000 Fu/g, ensuring a high-potency product suitable for pharmaceutical and nutraceutical applications.
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What are the optimal storage conditions for Nattokinase?
Nattokinase should be stored in a cool, dry, and dark environment at temperatures below 0°C. Exposure to high temperatures (above 80°C) or extreme pH conditions (below pH 5) will cause denaturation and inactivation of the enzyme. If improper storage occurs, an increase in dosage is recommended to compensate for activity loss.
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What are the main health benefits of Nattokinase?
Nattokinase supports cardiovascular and cerebrovascular health by dissolving blood clots and lowering blood lipids. It also supports hormone balance, detoxification, skin health, weight management, antioxidant activity, and anti-fatigue effects. Its excellent intestinal absorption makes it highly effective for boosting thrombolytic activity in the body.
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What packaging options and minimum order quantities are available?
We offer flexible packaging options: 1kg bags (double plastic + aluminum foil bag, boxed) and 10kg, 25kg or more in drums or cartons with 2-layer plastic bag inner lining. Please contact us for custom quantities and pricing.
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What shipping methods are available and how long does delivery take?
We ship worldwide via multiple methods: For orders of 1–25kg, we use EMS, DHL, UPS, or FedEx (3–7 days, door to door). For 25–100kg, DHL, FedEx, or air freight is available (3–7 days). For orders over 100kg, air freight (3–7 days to airport) or sea freight (10–35 days, door to port) is offered.
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