Nattokinase, also known as subtilisin (hereinafter referred to as NK), is a serine protease produced by Bacillus subtilis natto during the fermentation of natto. It can dissolve thrombi, reduce blood viscosity, improve blood circulation, soften blood vessels and enhance vascular elasticity.
Product Features
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Produced via liquid fermentation and nanobiotechnology, enabling precise extraction of active ingredients. The product's kinase activity exceeds 50,000 Fu/g.
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Compared with other thrombolytic drugs, Nattokinase (NK) offers advantages including low cost, high safety, small molecular weight, excellent oral efficacy, strong thrombolytic activity and long duration of action.
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Optimal reaction temperature: 30–45°C, with the best performance at 37°C; denatures and inactivates above 80°C. Optimal reaction pH: 6–9, with the best performance at pH 7.4; inactivates below pH 5.
Bacillus subtilis natto fermentation → Extraction → Horizontal spiral separation → Centrate → High-speed tubular centrifugation → Centrate → Microfiltration → Ultrafiltration Re-extraction ↖ Residue ↓ Discarding → Vacuum freeze-drying → Shatter → Blend → Detection → Packaging → Finished product ↑ ↑ acceptance acceptance ↑ ↑ Excipients Inner packaging bag
⚗️ Enzyme Activity Definition: Nattokinase reacts with fibrin to hydrolyze the peptide bonds of fibrin. The hydrolysis reaction changes the absorbance of the solution at 275 nm of ultraviolet light. One activity unit (1FU) refers to the energy consumed for every 0.01 increase in the absorbance value at 275 nm.
Frequently Asked Questions (FAQ)
Q1: What is Nattokinase and how is it produced?
Nattokinase (NK) is a serine protease derived from Bacillus subtilis natto during the fermentation of natto. It is produced using liquid fermentation combined with nanobiotechnology, which enables precise extraction of active ingredients, achieving a kinase activity exceeding 50,000 Fu/g.
Q2: What are the main health benefits of Nattokinase?
Nattokinase helps dissolve blood clots, lower blood lipids, reduce blood viscosity, and improve blood circulation. It also supports cardiovascular and cerebrovascular health, assists with weight management, offers antioxidant and anti-fatigue benefits, and helps slow the aging process.
Q3: What are the optimal storage conditions for Nattokinase?
Nattokinase should be stored in a cool, dry, and dark place at a temperature below 0°C. Exposure to high temperature or humidity may reduce enzyme activity. In such cases, an appropriate increase in dosage is recommended.
Q4: What temperature and pH conditions does Nattokinase work best under?
The optimal reaction temperature for Nattokinase is 30–45°C, with peak performance at 37°C. It denatures and inactivates above 80°C. The optimal pH range is 6–9, with best activity at pH 7.4; it inactivates below pH 5.
Q5: What packing options are available for bulk orders?
For 1kg orders, the product is packed in a bag/kg with a box outside (double plastic bag + aluminum foil bag inside). For 10kg, 25kg or larger quantities, packaging is available by drums or carton with 2 layers of plastic bag inside.
Q6: What delivery options are available and how long does shipping take?
For orders of 1kg–25kgs, shipping is available via EMS, DHL, UPS, or FedEx with a 3–7 day delivery time (door to door). For 25kg–100kg, DHL, FedEx, or Air freight is available in 3–7 days. For orders over 100kgs, air freight (3–7 days, door to airport) or sea freight (10–35 days, door to port) options are offered.