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Nattokinase, also known as subtilisin (hereinafter referred to as NK), is a serine protease produced by Bacillus subtilis natto during the fermentation of natto. It can dissolve thrombi, reduce blood viscosity, improve blood circulation, soften blood vessels and enhance vascular elasticity.
Bacillus subtilis natto fermentation → Extraction → Horizontal spiral separation → Centrate → High-speed tubular centrifugation → Centrate → Microfiltration → Ultrafiltration
Re-extraction ↖
Residue
↓
Discarding
→vacuum freeze-drying→Shatter→blend→Detection→packaging→finished product
↑ ↑
acceptance acceptance
↑ ↑
Excipients Inner packaging bag
| Test Items | Specification | Results | Method |
|---|---|---|---|
| Appearance | Fine Powder | Conforms | NLS-QCS-1008 |
| Color | Yellow white-off white | Conforms | GB/T 5492-2008 |
| Odor | Characteristic | Conforms | GB/T 5492-2008 |
| Taste | Characteristic | Conforms | GB/T 5492-2008 |
| Part Used | Seeds | Conforms | / |
| Drying Method | Freeze drying | Conforms | / |
| Physical Characteristics | |||
| Particle Size (80 mesh) | NLT 95% through 80 mesh | Conform | GB/T 5507-2008 |
| Moisture | <5.0% | 3.8% | GB/T 14769-1993 |
| Ash Content | <5.0% | 2.6% | AOAC 942.05, 18th |
| Solvent Residue | Eur Pharm | Conform | NLS-QCS-1007 |
| Heavy metals | |||
| Total Heavy Metals | <10ppm | Conform | USP <231>, method II |
| As | <2.0ppm | Conform | AOAC 986.15, 18th |
| Pb | <2.0ppm | Conform | AOAC 986.15, 18th |
| Cd | <0.5ppm | Conform | AOAC 986.15, 18th |
| Hg | <0.5ppm | Conform | AOAC 971.21, 18th |
| Pesticide Residue | |||
| 666 | <0.2ppm | Conform | GB/T5009.19-1996 |
| DDT | <0.2ppm | Conform | GB/T5009.19-1996 |
| Microbiological Tests | |||
| Total Plate Count | <1,000cfu/g | Conform | AOAC 990.12, 18th |
| Total Yeast & Mold | <100cfu/g | Conform | FDA (BAM) Chapter 18, 8th Ed. |
| E. Coli | Negative | Negative | AOAC 997.11, 18th |
| Salmonella | Negative | Negative | FDA (BAM) Chapter 5, 8th Ed. |
Keep in a cool, dry and dark place. Storage temperature: below 0°C. Prolonged or improper storage may reduce enzyme activity. If exposed to high temperature or humidity, an appropriate increase in dosage is recommended.
| Weight | Packing method |
|---|---|
| 1kg | bag/kg, box outside (double plastic bag + Aluminum foil bag inside) |
| 10kgs, 25kg or more | by Drums or carton (2 layers plastic bag inside) |
| Weight | Delivery method | Delivery time | Destination |
|---|---|---|---|
| 1kg-25kgs | EMS, DHL, UPS, Fedex | 3-7days | Door to door |
| 25kgs-100kgs | DHL, FedEx, by Air | 3-7days | Door to door (to Airport by Air) |
| more than 100kgs | by Air | 3-7days | Door to Airport |
| by Sea | 10-35days | Door to port |
