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Oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) is a naturally occurring polyphenol structural analogue of resveratrol, primarily derived from the heartwood of Morus alba L. (Mulberry) and Artocarpus lakoocha. Over the last decade, high-efficacy cosmetics, nutraceutical formulation pipelines, and clinical dermatological therapies have turned their focus toward Oxyresveratrol due to its exceptional therapeutic profile, particularly in skin pigmentation disorders and oxidative stress mitigation.
Global procurement metrics show a compound annual growth rate (CAGR) of 8.6% for Oxyresveratrol. The market size is projected to reach unprecedented peaks by 2030, driven by the clean-label beauty movement in North America and Western Europe, alongside rising clinical research in APAC validating its multi-pathway biological applications. Commercial demand has shifted from semi-purified raw wood dust to standardized, ultra-pure crystallized powders (≥98% HPLC) with strict regulations on polycyclic aromatic hydrocarbons (PAHs) and residual solvents.
“According to industrial phytochemistry reports, Oxyresveratrol exhibits a tyrosinase inhibition efficacy (IC50) up to 150 times stronger than resveratrol, positioning it as the ultimate natural gold standard for hyperpigmentation correction.”
Understanding the structural advantages of stilbenoids is crucial for formulators and B2B buyers. Below is an exhaustive comparison of the key active compounds in this class, highlighting why premium buyers prioritize Oxyresveratrol for advanced formulations.
| Parameter / Compound | Resveratrol | Oxyresveratrol | Pterostilbene |
|---|---|---|---|
| Chemical Structure | trans-3,5,4'-trihydroxystilbene | trans-2,4,3',5'-tetrahydroxystilbene | trans-3,5-dimethoxy-4'-hydroxystilbene |
| Tyrosinase Inhibition (IC50) | Moderate (~26.6 μM) | Extremely High (~1.2 μM) | Low / Inactive |
| Free Radical Scavenging (DPPH) | Strong | Excellent (due to four active hydroxyl groups) | Moderate |
| Water Solubility | Poor (<0.05 mg/mL) | Significantly Improved (~0.4 mg/mL) | Extremely Poor |
| Bioavailability Rate | Low (~20% systemic absorption) | Higher initial mucosal absorption rate | High (due to lipophilic methoxy groups) |
| Principal Applications | Cardiovascular health, Anti-aging | Dermal whitening, Anti-inflammatory, Neuroprotection | Cognitive health, Metabolic support |
The addition of the hydroxyl group (-OH) at the 2-position on the benzene ring of Oxyresveratrol significantly enhances its water solubility and affinity for active enzyme binding sites. This structural variation makes it uniquely effective in treating hyperpigmentation, melasma, and age spots by directly blocking dopa oxidase activity.
Shaanxi ShineHerb Biotech Co., Ltd. is a professional enterprise engaged in the research, production, and exports of Enzyme preparations, Natural plant extracts, Vitamins, Amino acids, and Pharmaceutical intermediates. We are committed to providing global customers with competitive pricing, stable and reliable product quality, and professional, efficient services.
With over 20 years of experience in the raw materials industry, ShineHerb Biotech continues to strengthen its technical capabilities and improve product quality. Our main products include Lactase, Bromelain, Pancreatin, Papain, Quercetin, N-Acetyl-L-Cysteine (NAC), PQQ, and Glucosamine Sulfate 2KCL, among others. These ingredients are widely used in pharmaceuticals, dietary supplements, beverages, cosmetics, and food additives.
At present, our products are exported to more than 50 countries and regions, including Europe, North America, and Southeast Asia, and have gained wide recognition and trust from customers worldwide.
For procurement officers in major cosmetic conglomerates and pharmaceutical labs, sourcing Oxyresveratrol is complex. Because the raw botanical source material (Morus alba wood or bark) must be processed through complex isolation steps, buyers face several risks. These include batch-to-batch variation, residual solvent contamination, and structural degradation caused by light and heat exposure.
Ensure manufacturers provide HPLC chromatogram results showing ≥98% active trans-Oxyresveratrol. Lower purity grades can contain natural impurities that cause cosmetic formulation darkening over time.
Cosmetic application standards demand green extraction routes. Solvent residues (especially Class 1 and Class 2 solvents like methanol or toluene) must remain well below USP/EP limits, typically under 50 ppm.
Reputable manufacturers must furnish real-time and accelerated stability studies (usually 24 to 36 months) detailing the rate of trans-to-cis isomerization under varying temperature, pH, and exposure conditions.
B2B Sourcing Insight: High-grade Oxyresveratrol is highly sensitive to UV exposure. Reliable suppliers package the compound in double food-grade anti-static bags, sealed inside light-blocking aluminum foil drums flushed with inert nitrogen gas.
China is a global leader in high-throughput plant extract manufacturing. Modern Chinese extraction facilities have transitioned to "Factory 4.0" automation models. Through digital process control systems, advanced chromatography columns, and computerized spray-dryers, manufacturers achieve consistent yields and low batch-to-batch variation.
Key supply chain advantages of partnering with Shaanxi ShineHerb Biotech Co., Ltd. include:
Quality is the foundation of our business. Our operations adhere strictly to GMP guidelines, supported by international safety and compliance certifications.
We maintain a rigorous quality management system covering raw material inspection, production control, solvent management, and final testing to ensure compliance with USP, EP, and CP standards.
Our experienced R&D team assists with application issues, formulation design, stability optimization, and regulatory documentation for global registrations.
Our production facilities feature state-of-the-art HVAC systems, cleanrooms, and automated equipment designed to meet international Good Manufacturing Practices.
Good Manufacturing Practice • Rigid Production Standards
Global Standard Recognition • Meet International Requirements
U.S. Food & Drug Administration Registered Facility
Quality and Purity Checked by Global Third-Party Auditors
Depending on the target market, Oxyresveratrol must be formulated and certified to meet distinct regulatory frameworks. Here is how key regional markets utilize this active ingredient:
Regulatory Compliance: REACH Registered, CosIng Database Approved.
Primary Application: Anti-aging night creams and clinical hyperpigmentation treatments. Due to EU regulations on synthetic cosmetic active concentrations, formulators prefer our natural-source, eco-extracted Mulberry wood extract standardized to 98% Oxyresveratrol.
Regulatory Compliance: DSHEA Compliant (for dietary supplements), GRAS evaluation pipelines.
Primary Application: Advanced oral dietary supplements targeting cognitive health and metabolic wellness. Formulators pair Oxyresveratrol with piperine to improve intestinal absorption rates and prolong systemic half-life.
Regulatory Compliance: IECIC listed (China), Quasi-Drug standards (Japan).
Primary Application: Dermal brightening serums, sheet masks, and essence products. Our specialized technical grade features micronized particles to facilitate easy dissolution in polyols, helping prevent sedimentation in high-water-content formulas.
At Shaanxi ShineHerb Biotech Co., Ltd., we offer contract manufacturing services to bring your brand's unique concepts to life. From formulation design and packaging layout to production and final compliance clearance, our one-stop service streamlines your launch process.
We provide hassle-free global shipping to ensure raw materials arrive safely and on schedule. Our logistics team handles international clearance, import declarations, and compliance paperwork for various destinations.
Find answers to technical, formulation, and procurement questions compiled by our laboratory specialists and quality control team.
Our Oxyresveratrol is primarily extracted from the heartwood of Morus alba L. (Mulberry tree). We extract the compound using green solvents to achieve high purity (98% HPLC) while avoiding residual chemical contaminants.
Oxyresveratrol has an additional hydroxyl group on its benzene ring. This structure increases its water solubility, free-radical scavenging capacity, and affinity for tyrosinase active sites. Research indicates its tyrosinase inhibition is up to 150 times stronger than standard Resveratrol.
Oxyresveratrol can be sensitive to light and heat, which may lead to discoloration. To stabilize it, we recommend using chelating agents, maintaining a pH range of 5.5 to 6.5, or utilizing liposomal and micro-encapsulation delivery systems.
For standard pilot orders, our minimum order quantity starts at 1 kg. For bulk commercial contracts, we supply in standard 25 kg fiber drums. We can also provide custom packaging for special formulation requirements.
Yes. Every batch is tested in-house and verified by third-party laboratories. We provide comprehensive documentation for each shipment, including Certificates of Analysis (COA), heavy metal profiles (ICP-MS), and microbiological tests.
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