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Diosmetin (Chemical Formula: C16H12O6, CAS No. 520-12-7), also systematically known as 3',5,7-Trihydroxy-4'-methoxyflavone, is a powerful natural monomethoxyflavone. It represents the aglycone structure obtained via the cleavage of the sugar moiety from the glycoside diosmin. Structurally, it is directly related to luteolin, but features a critical 4'-methoxy substitution on the B-ring, which profoundly enhances its lipophilicity and subsequent cellular permeability compared to other unmodified polyhydroxylated flavonoids.
Historically, nutritional sciences relied heavily on raw Diosmin. However, modern metabolic research has revealed that Diosmin acts primarily as a prodrug. Upon oral ingestion, it is hydrolyzed by intestinal microflora into the bio-efficacious aglycone Diosmetin before systemic absorption. By supplying raw, ultra-pure Diosmetin 99%, manufacturers bypass the variable microfloral conversion rate, providing direct, standardized bioavailability for metabolic pathways. This makes Diosmetin the preferred choice for next-generation vascular, antioxidant, and tissue-protective formulations.
Our R&D division has validated multiple cell-signaling pathways influenced by Diosmetin 99%:
| Analysis Parameter | Specification Target | Methodology / Standard |
|---|---|---|
| Assay (Purity) | ≥ 99.0% (Dry Basis) | High-Performance Liquid Chromatography (HPLC) |
| Appearance | Light Yellow to Greenish-Yellow Crystalline Powder | Visual Inspection |
| Loss on Drying | ≤ 1.0% | USP <731> Gravimetric Method |
| Heavy Metals (as Pb) | ≤ 10 ppm | ICP-MS Method |
| Residual Solvents | Meets USP <467> Requirements (Ethanol Only, Methanol Free) | Gas Chromatography (GC-FID) |
| Particle Size | 90% through 80 Mesh (Micronized grades available up to < 10 microns) | Sieve Analyzer / Laser Particle Size Distribution |
Shaanxi ShineHerb Biotech Co., Ltd. is a professional enterprise engaged in the research, production, and export of Enzyme preparations, Natural plant extracts, Vitamins, Amino acids, and Pharmaceutical intermediates. We are committed to providing global customers with competitive pricing, stable and reliable product quality, and professional, efficient services.
With over 20 years of experience in the raw materials industry, ShineHerb Biotech continues to strengthen its technical capabilities and improve product quality. Our main portfolio features core items such as Lactase, Bromelain, Pancreatin, Papain, Quercetin, N-Acetyl-L-Cysteine (NAC), PQQ, and Glucosamine Sulfate 2KCL, among others. These ingredients are widely used in pharmaceuticals, dietary supplements, beverages, cosmetics, and food additives.
At present, our products are exported to more than 50 countries and regions, including Europe, North America, and Southeast Asia, and have gained wide recognition and trust from customers worldwide.
From advanced microvascular medicine to targeted dermal formulas, Diosmetin 99% is utilized globally according to specific regional regulatory and consumer demands.
Microvascular & Venous Health Supplements
In these mature markets, Diosmetin is a critical ingredient in clinical-grade formulas targeting Chronic Venous Insufficiency (CVI), varicose veins, and hemorrhoidal flare-ups. Used frequently as a standalone or in synergistic combination with micronized purified flavonoid fractions (MPFF), its 99% pure powder form is optimized for capsules and tablets to maximize metabolic transit.
Nutricosmetics & Functional Skincare
In Japan, South Korea, and China, Diosmetin 99% is increasingly formulated into high-end topicals and oral beauty liquids. Thanks to its dual action of inhibiting cellular melanin synthesis (via tyrosinase inhibition) and blocking UV-induced inflammatory matrix metalloproteinases (MMPs), it serves as a highly stable, non-irritating whitening and anti-photoaging agent.
Sport Performance & Metabolic Synergy
Formulators are exploring Diosmetin for cardiovascular endurance and metabolic support. By protecting endothelial integrity, it assists nitric oxide (NO) dynamics to optimize oxygen delivery to muscles. Its clean-label botanical status complies perfectly with the Halal and Kosher certification requirements of these regions.
Our dedicated R&D division has spent years refining the production methodology of Diosmetin. Here is our technological roadmap detailing the transition from traditional extraction to sustainable green biocatalysis.
Extraction of crude Hesperidin from citrus peels (such as Citrus aurantium L.). The process utilizes high-efficiency counter-current extraction systems with water and food-grade ethanol, eliminating chlorinated solvent risks.
Hesperidin is converted into Diosmin via mild catalytic dehydrogenation. Following this, targeted enzymatic cleavage of the glycosidic linkage (using engineered beta-glucosidase enzymes) liberates the highly pure Diosmetin aglycone.
Crude Diosmetin is purified using multi-stage recrystallization to achieve ≥99.0% purity. Our facility then offers jet-milling technology to produce micronized particle distributions for optimized dissolution kinetics.
Due to the planar crystalline structure of flavonoids, raw Diosmetin exhibits low water solubility. ShineHerb Biotech's research team is currently developing Self-Microemulsifying Drug Delivery Systems (SMEDDS) and Cyclodextrin Complexation protocols. These pilot methods have demonstrated up to a 500% increase in vitro dissolution rates, presenting an exciting development for clients seeking high-efficacy finished products.
Operating from the High-Tech Zone in Xi'an, Shaanxi Province, ShineHerb Biotech manages an end-to-end supply chain designed for consistent quality and reliable delivery.
Leveraging China's vast citrus agricultural belt, we secure steady volumes of raw material year-round. This keeps our production decoupled from single-region crop failures and maintains stable pricing for long-term contract partners.
Our advanced facilities utilize automated stainless steel extraction batteries, clean rooms, and high-precision testing equipment. Every batch undergoes strict compliance audits to meet USP, EP, and CP guidelines.
We offer global DDU/DDP services via air, ocean, and international rail corridors. Partnered with major carriers like FedEx, DHL, and UPS, we ensure hassle-free customs clearance and direct delivery.
From formulation design to production and custom packaging, ShineHerb Biotech manages every stage of contract manufacturing so you can focus on building your brand. We deliver solutions across multiple formats:
We coordinate express shipping (FedEx, DHL, UPS) as well as commercial air, sea, and rail freight to fit your timeline and budget.
Take an inside look at our manufacturing facility and advanced processing lines in Xi'an, China.
Every batch of Diosmetin 99% and related botanical extracts undergoes rigorous testing to verify compliance with global safety and quality criteria.
Guaranteed Food Safety Management
Good Manufacturing Practice
Certified for All Dietary Needs
Global Standard Recognition
U.S. FDA Compliant Ingredients
Rigorous Quality Control Verified
Suitable for Muslim Consumers
Find quick answers to technical specifications, order logistics, and formulation guidelines for Diosmetin 99%.
Explore the second part of our certified ingredients catalog, produced to support diverse food, feed, cosmetic, and pharmaceutical formulations worldwide.
Looking ahead, ShineHerb Biotech will continue to focus on reliable quality and responsive service to meet customer needs. We place great importance on building long-term, stable partnerships with our customers, and are committed to providing global clients with reliable product quality and professional services. Request technical dossiers, specification sheets, and batch samples from our team.
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