Shaanxi ShineHerb Biotech Co., Ltd. is a premier, GMP-compliant global enterprise dedicated to the research, synthesis, purification, and industrial scale production of Enzyme preparations, Natural plant extracts, Vitamins, Amino acids, and Pharmaceutical intermediates.
With an intensive footprint spanning over 20 years in raw ingredient sourcing, we operate in the High-Tech Industrial Zone of Xi’an, Shaanxi Province—the epicentre of botanical extraction innovation in China. Our client base spans across 50+ countries and regions, including North America, Europe, and Asia-Pacific. We provide active ingredients verified by international quality control standards, ensuring cost performance and supply stability.
Decoding the structural and pharmacological properties of one of the industry's most potent protoberberine alkaloids.
Palmatine is a natural quaternary ammonium protoberberine alkaloid primarily isolated from plant stems and roots of medicinal species like Fibraurea recisa, Coptis chinensis, Stephania yunnanensis, and Phellodendron amurense. Our industrial manufacturing process ensures ecological and sustainable raw plant harvesting.
With chemical formula C21H22NO4+ and CAS Registry Number 3486-67-7 (often commercialized as Palmatine Hydrochloride), it presents as a distinct yellow crystalline powder. In contrast to berberine, it possesses two methoxy groups at positions C-2 and C-3, altering its interaction profile.
Extensive pharmacological studies document Palmatine's significant gastrointestinal protection, broad-spectrum antimicrobial activity, selective anti-inflammatory pathway inhibition (NF-κB), and neuroprotective properties. It serves as a key active pharmaceutical ingredient (API) globally.
How international pharmaceutical and nutraceutical manufacturers optimize their supply chains.
In the current global health ingredients market, buyers face the double challenge of finding suppliers who offer both high purity and competitive pricing. Commercial demand for Palmatine and its derivatives (such as Palmatine Hydrochloride or Palmatine Sulfate) has risen rapidly due to the trend toward clean-label botanical APIs.
Procurement departments at large-scale health supplement brands, animal feed formulation factories, and pharmaceutical laboratories prioritize batch-to-batch consistency. The presence of residual solvents, heavy metal margins, and microbiological counts must meet strict international standards (USP, EP, CP). By working directly with a primary extraction factory, bulk buyers can secure supply lines, lower transactional risks, and ensure transparency in their raw material supply.
From raw botanical sourcing to advanced chromatography purification: How our factory guarantees quality.
Sustainable wild cultivation of Fibraurea recisa and Coptis chinensis. The raw botanical bark and roots undergo strict identification, macroscopic inspection, and moisture control (below 12%) before entry into the extraction chambers.
Utilizing food-grade ethanol and aqueous solvent mixes under optimized thermal conditions. Countercurrent extraction maximises the yield of alkaloids while preserving the target active chemical structure.
The raw extract is passed through macro-porous adsorption resins to isolate Palmatine from adjacent alkaloids (like berberine and jatrorrhizine). Successive recrystallization steps achieve high-purity yellow needle crystals.
"By combining advanced chromatography separation with green chemistry principles, we reduce water and energy footprint by 35% compared to traditional extraction methods." — ShineHerb Technical Director
Addressing formulation challenges to unlock the full potential of Palmatine in global markets.
While Palmatine exhibits excellent therapeutic properties, its quaternary ammonium structure limits its oral bioavailability and intestinal absorption. To help pharmaceutical and supplement manufacturers create effective products, ShineHerb Biotech provides customized solutions:
ShineHerb Biotech is a contract manufacturing partner (OEM/ODM). We handle the process from raw ingredient sourcing to final product formulation in multiple formats:
Providing security and efficiency throughout the supply chain.
Our quality management system tracks raw materials from intake to final packaging. We test every batch using HPLC, GC, LC-MS, and ICP-MS systems to confirm purity, potency, and safety.
Our team includes phytochemists and process engineers with over 20 years of experience. We provide complete technical documentation, including Certificate of Analysis (CoA), MSDS, Allergen Statements, and compliance paperwork.
Our factory maintains high extraction capacity to guarantee a continuous supply. We run clean, high-throughput extraction lines that allow us to process multi-ton orders without batch delays.
A glimpse inside our production workshops, warehouse, and clean rooms.
Our manufacturing facilities conform to rigorous safety standards, facilitating export to the US, EU, and other global regions.
Hazard Analysis Critical Control Point
Good Manufacturing Practice Standards
Certified for All Dietary Needs
ISO9001 Quality Management Certified
U.S. FDA Food Facility Registration
Third-party Quality Audit Verification
Muslim Consumption Halal Certified
To maintain the biological activity and shelf-life of our botanical ingredients, ShineHerb Biotech offers temperature-controlled packaging and specialized shipping. We support multi-channel logistics to keep lead times predictable.
Watch our factory process videos to see our raw material production and quality control in action.
Direct answers to technical, commercial, and regulatory questions for bulk buyers.
Our raw material is extracted primarily from high-grade Fibraurea recisa stems and Coptis chinensis roots. We source these from ethical, sustainable growers to protect local ecosystems while ensuring high concentration of active compounds.
Our standard pharmaceutical and supplement grade Palmatine Hydrochloride features a minimum assay of 98.0% by HPLC. We can customize purity levels, mesh sizes, and density requirements to match your formulation needs.
Yes. Every batch leaves our facility with an in-house Certificate of Analysis (CoA). Upon request, we can coordinate third-party testing with SGS, Eurofins, or Intertek to verify purity, heavy metals, pesticide residues, and microbial counts.
For standard in-stock inventory, dispatch occurs within 3-5 working days. High-volume custom contract manufacturing orders require 15-20 days from formula confirmation to loading. We coordinate logistics through air, sea, and rail channels.
Our technical team helps clients select the best options for liquid supplements. We offer micronization, liposomal delivery systems, and organic salt alternatives to improve dispersion and bioavailability in final products.
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