Explore our curated selection of bioactive compounds, industrial enzymes, and natural botanical extracts produced under rigid GMP compliance.
Published by Shaanxi ShineHerb Biotech Co., Ltd. R&D Division
Natural bioactive peptides have fundamentally reshaped modern medical therapeutics and advanced dermo-cosmetics. Among the most potent microcirculation regulators is Leech Extract, containing Hirudin—a highly specific, natural direct thrombin inhibitor. Derived from selected medicinal leeches (specifically *Hirudo medicinalis* and *Hirudo nipponica*), natural leech extract offers unparalleled biological advantages over synthetic anticoagulants and generic anti-inflammatory agents. This comprehensive white paper discusses the biochemical mechanisms, application profiles, and global supply chain dynamics of standardized leech extract raw materials.
To ensure high efficacy, Leech Extract must be standardized by measuring its antithrombin activity in Antithrombin Units (ATU) per gram. Natural Hirudin forms a stable, non-covalent, stoichiometric complex with thrombin, neutralizing its capacity to convert fibrinogen into fibrin. This specific mode of action prevents microvascular thrombogenesis and alleviates deep tissue congestion.
| Specification Metric | Standard Powder Grade | Premium Biopharma Grade | Cosmetic Actives Grade |
|---|---|---|---|
| Biological Activity (ATU/g) | ≥ 100 ATU/g | ≥ 800 - 1,200 ATU/g | ≥ 200 - 400 ATU/g |
| Physical Appearance | Light-yellow to brown powder | Off-white freeze-dried powder | Yellowish clear liquid / dry powder |
| Solubility in H2O | Highly soluble (100% water-soluble) | Instantaneous complete solubility | Complete solubility without turbidity |
| Heavy Metals (Pb, As, Cd, Hg) | < 10 ppm | < 3 ppm | < 5 ppm |
| Assay Method | Chromogenic substrate assay | HPLC / Thrombin titration | Chromogenic substrate assay |
As a leading exporter of botanical extracts and active pharmaceutical ingredients (APIs), Shaanxi ShineHerb Biotech Co., Ltd. operates in strict compliance with global quality and safety guidelines. Our Leech Extract undergoes validation protocols designed to meet international standards:
China is home to some of the world's most advanced biological extraction facilities. Shaanxi ShineHerb Biotech leverages these domestic supply chain advantages to benefit our global clients:
Modern applications of Leech Extract cross several medical and cosmetic fields, driven by its direct microcirculation advantages:
Welcome to learn about Shaanxi ShineHerb Biotech Co., Ltd.
Shaanxi ShineHerb Biotech Co., Ltd. is a professional enterprise engaged in the research, production, and exports of Enzyme preparations, Natural plant extracts, Vitamins, Amino acids, and Pharmaceutical intermediates. We are committed to providing global customers with competitive pricing, stable and reliable product quality, and professional, efficient services.
With over 20 years of experience in the raw materials industry, ShineHerb Biotech continues to strengthen its technical capabilities and improve product quality. Our main products include Lactase, Bromelain, Pancreatin, Papain, Quercetin, N-Acetyl-L-Cysteine (NAC), PQQ, and Glucosamine Sulfate 2KCL, among others. These ingredients are widely used in pharmaceuticals, dietary supplements, beverages, cosmetics, and food additives.
At present, our products are exported to more than 50 countries and regions, including Europe, North America, and Southeast Asia, and have gained wide recognition and trust from customers worldwide.
Cooperation is just the beginning, and our service never ends. Here is why global enterprises partner with us.
We maintain a rigorous quality management system covering raw materials, production processes, solvent management, and final testing. Products comply with USP, EP, and CP requirements.
Our experienced R&D team provides full formulation support, regulatory assistance, and custom specifications to meet your requirements.
Our production facilities strictly adhere to GMP requirements. We welcome third-party audits and offer comprehensive traceability records.
Shaanxi ShineHerb Biotech operates a diverse biotechnology ecosystem, providing raw materials to support your production.
Stable enzyme activity, Customizable Specifications. Food, Feed, Pharma, and Cosmetic Grade. FCC, FDA, Halal, Kosher Certified.
Nature-Derived Ingredients for health, weight loss, immune boost, eye health, and custom formulas.
Amino Acids, Vitamins, Minerals, Probiotics, Natural Fruit & Vegetable Powders, and Sweeteners.
Cosmetic peptides, active agents for cleansing, sun protection, anti-aging, whitening, and exfoliation.
Manufactured to GMP Standards, ISO9001 quality verified, ensuring batch-to-batch consistency.
Our globally requested product formulations designed for high stability and biocompatibility.
ShineHerb Biotech maintains strict alignment with global food safety, purity, and manufacturing standard frameworks.
Compliant Batch Testing
Cleanroom Standard Validation
Food Facility Verification
Quality System Audited
Third Party Chemical Purity
Approved Global Supply
Pure Dietary Integrity
Risk-Controlled Food Safety Management
Rigid Production Standards
High-Quality Certification for All Needs
Global Standard Recognition & compliance
Safe Ingredients for Global Markets
Verified Quality Control by Global Leader
Expand Your Market Reach in MENA Regions
Custom Dietary Supplement Manufacturing | Powder, Tablets, Capsules, Gummies, Solid Beverages
From fine powders to convenient tablets, from easy-to-swallow hard capsules to highly absorbable softgels, and nutritious gummies—ShineHerb Biotech offers full-format customized manufacturing. We handle every step so you can focus on building your brand.
Efficient multi-channel shipping combined with transparent industrial processes.
Take a virtual tour of our state-of-the-art biological processing facilities and quality assurance cleanrooms.
Learn more about our enzymatic degradation processes, low-temperature drying parameters, and standardization methods.
To support global manufacturers, we offer customized logistics solutions to ensure prompt delivery:
FedEx, DHL, UPS & EMS
FCL & LCL options
Belt & Road transport
Tax & duty clearance handled
Answers to technical and regulatory questions about Leech Extract and Hirudin raw materials.
Natural Hirudin binds directly to thrombin, preventing it from activating fibrinogen. This microvascular antithrombin effect reduces vascular pooling, helps clear dark circles, minimizes under-eye bags, and relieves minor local swelling or hematomas when applied topically.
We measure active hirudin in Antithrombin Units (ATU) per gram. This is determined via a chromogenic substrate assay or thrombin titration method, verifying the precise inhibition curve against standardized thrombin controls.
Yes, our cosmetic grade Leech Extract is derived from aquaculture-bred leeches free from pathogenic pollution and heavy metals. We use a low-temperature filtration process that maintains purity and safety without toxic solvents, matching global cosmetic ingredient guidelines.
Our freeze-dried Leech Extract powder has a shelf life of 24 months when stored in a cool, dry place inside tightly sealed original containers. Avoid direct exposure to heat, light, and humidity to prevent denaturation of the bioactive peptides.
Yes, we provide OEM and ODM manufacturing services. We can process Leech Extract or other active ingredients into custom powders, tablets, capsules, liquids, or topical creams, complete with customized packaging and label compliance support.
Complementary high-purity vitamins, peptides, and functional excipients for your pharmaceutical and supplement manufacturing lines.
ShineHerb